中文名稱    MREG蛋白抗體  
英文名稱    MREG      
別    名    Dilute suppressor; Dilute suppressor protein homolog; DSU; Melanoregulin; MGC90296; MREG; WDT 2; WDT2; Whn dependent transcript 2; MREG_HUMAN.    
規    格    0.1ml  0.2ml      
研究領域    心血管  細胞生物  免疫學      
抗體來源    Rabbit    
克隆類型    Polyclonal    
交叉反應    Human, Mouse, Rat,     
產品應用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 MREG蛋白抗體（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    25kDa    
細胞定位    細胞膜     
性    狀    Lyophilized or Liquid    
濃    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DSU/MREG    
亞    型    IgG    
純化方法    affinity purified by Protein A    
儲 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

MREG蛋白抗體產品介紹    background:
The photoreceptor rod cell that is responsible for vision under conditions of low light consists of stacked arrays of disk membranes that make up its outer segment portion. Regulated by complex biochemical mechanisms, the rod outer segment is under constant renewal as new disks form at the base. MREG is thought to play a role in membrane fusion and in regulating the biogenesis of disk membranes of photoreceptor rods. MREG interacts with RDS (also known as Peripherin-2), a photoreceptor specific tetraspanin protein that is required to maintain normal cell structure during the renewal process of membrane fusion. MREG is 214 amino acids in length, is expressed in photoreceptor cells and and is expressed as two isoforms due to alternative splicing.

Function:
Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).

Subunit:
Interacts with PRPH2 (By similarity).

Subcellular Location:
Apical cell membrane; Peripheral membrane protein.

Tissue Specificity:
Expressed in photoreceptor cells (at protein level).

Similarity:
Belongs to the melanoregulin family.

Database links:
Entrez Gene: 55686 Human
Entrez Gene: 381269 Mouse
Omim: 609207 Human
SwissProt: Q8N565 Human
SwissProt: Q6NVG5 Mouse

important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.